Endocrine Abstracts

Aims: To determine the relationships between calcium:creatinine (CaCr) clearance ratio and fractional excretion of calcium (FECa).Design: Ten-week study of 15 patients aged 25–93 years undergoing investigations for parathyroid hormone (PTH)-related hypercalcaemia and 39 healthy volunteers aged 20–61 years.Outcome measures: CaCr clearance ratio calculated from 24-hour urine collection and FECa from 5 ml fasting urine aliqu...

Aims: To assess the short-term (one day) and longer-term (10–113 days) test-retest reliability of calcium:creatinine (Ca:Cr) ratio calculated from 24-hour urine collection and its surrogate fractional excretion of calcium (FECa) from urine aliquots.Methods: On the first visit, eight subjects (aged 22–55 years) collected two fasting urine aliquots (5 ml) at the start and end of their non-fasting 24-hour urine collection for FECa<...

Aims: To assess factors associated with excess rates of fractures in women with Turner’s syndrome.Settings: Adult Turner Clinic.Outcome measures: Bone fracture history, oestrogen, growth hormone, oxandrolone and thyroxine therapies, anthropometry, calcium, vitamin D, parathyroid hormone and karyotype, hearing impairment, spinal bone mineral density (BMD). This study was approved by Ethical Committee.Resu...

Objectives: To compare height and body proportions between women with complete androgen insensitivity syndrome (CAIS) and women with gonadal dysgenesis (GD).Design: Cross-sectional study of three groups of women with varying degrees of exposure to sex hormones and different combinations of sex chromosomes. Fourteen subjects had CAIS and 46XY (CAIS(XY)), aged (mean±S.E.M.) 42.1±2.8 years; seven had GD and 46XY (GD(XY)), aged 36.7&...

Aims: To compare bone mineral density (BMD) and stature between women with androgen insensitivity syndrome and women with gonadal dysgenesis.Settings: Adult Intersex Clinic.Design: Retrospective cross-sectional study of three groups of women aged 17-58 years with varying degrees of exposure to sex hormones and different combinations of sex chromosomes. Forty-six subjects had complete androgen insensitivity syndrome and 46XY [CAIS(X...

Background: Quality of life (QoL) has been variously reported as normal or impaired in congenital adrenal hyperplasia (CAH) adults. We found impaired QoL in UK CAH adults (Arlt et al. Journal of Clinical Endocrinology and Metabolism 2010 95 5110–5121) and now report the relationship between QoL (SF-36) and health outcomes in these patients.Methods: Cross-sectional analysis of 151 CAH adults with 21-hydroxylase defi...